Micky van de Ven Brace Halts The Toffees' Run at Brand New Stadium
The Dutch defender became the first backline player to score two goals in a Premier League match for Spurs since the Belgian defender in spring 2013.
At a glance
Micky Van de Ven nods home two times in first half
Everton's Jake O'Brien has goal ruled after video check
Pape Matar Sarr scores final goal in 89th minute
The defeat is the Merseyside club's initial at Hill Dickinson Stadium
The Tottenham defender found the net on two occasions as Spurs extended their unbeaten run in away games in the top division and handed the Toffees their initial loss at their new home.
The Toffees were undefeated in their last five matches at their recently opened stadium at the dockside location, having departed Goodison Park behind after more than a century at the conclusion of last season.
But Spurs captain Van de Ven struck twice from corners in the first half to put their impressive record at risk, and they were failed to turn it around before Pape Matar Sarr - assisted by ex-Everton forward Richarlison - headed home a final goal to seal the victory.
Jake O'Brien thought he had levelled the scores five minutes after the defender's first goal, directing a powerful header past the Spurs keeper from an Everton corner.
The Portuguese striker, meanwhile, missed a number of opportunities, while Vicario made a series of excellent stops to guarantee Tottenham went five away games without defeat in the English top flight.
But the VAR stepped in, instructing Craig Pawson to review the score on the pitchside monitor and the referee decided that Jack Grealish and the attacker were in offside positions and had interfered with the Spurs keeper.
The win moves the manager's team up to third in the division, a handful of points off local foes and leaders Arsenal.
The Merseyside club remain 14th and are half a dozen points ahead of the drop zone.
Tottenham analysis: The defender fulfils role at each end of the field
Following a uninspiring midweek performance in the Champions League against the French side, where they managed a mere attempts on goal, Frank chose Randal Kolo Muani in attack instead of former Toffees player the Brazilian.
The new arrival was failed to influence the game before being substituted for the substitute after 60 minutes on the pitch, but it emerged he proved unnecessary in the final outcome.
Centre-back Van de Ven transformed into an offensive threat to be feared.
Spurs' opening strike came from a cleverly executed corner routine, with Rodrigo Bentancur heading the ball back across the face of goal for an free Van de Ven to head home.
And Ven de Ven - filling in as captain in Cristian Romero's absence - added his next goal in first-half stoppage time as he rose above the England keeper to head home.
Van de Ven was just as impressive in defence, combining well with his defensive colleague as the pair dealt excellently with the 34 crosses sent their way by Everton.
Toffees breakdown: Everton lacking striker's instinct
Everton's new home had been a fortress, but it seems the novelty may have faded somewhat and supporters headed to the exits after Sarr's third for Tottenham.
The break in the team's unbeaten home run won't be a massive worry for David Moyes, but their attacking woes are.
Beto and Thierno Barry - the Everton's pair of recognised centre-forwards - had netted only a single goal between them before the weekend's match.
And they were failed to add to that poor tally on a wet and gloomy evening on in Liverpool.
Beto's performance was summed up when he chose to overhead kick a golden opportunity from close range, even with having space and time to reposition for a simpler shot that would have challenged the keeper.
The substitute, too, was unable to influence the game after replacing Beto in the 65th minute.
It wasn't for a shortage of chance. The majority of Everton's offensive moves came through the winger and the forward, who relentlessly delivered dangerous crosses into the Spurs box.
What next for these two sides?
Everton: The team head to Sunderland in the top flight on early November at 8 PM.
Spurs: Spurs travel to St James' Park on Wednesday, 29 October for their fourth-round League Cup tie against Newcastle.